Product Description

HepBest 25 mg Tablet contains Tenofovir Alafenamide 25 mg, an antiviral medicine used for the treatment of chronic hepatitis B virus (HBV) infection in adults and adolescents with appropriate clinical indications. It belongs to the nucleotide reverse transcriptase inhibitor class and helps suppress HBV replication.
Tenofovir alafenamide works by inhibiting HBV reverse transcriptase, reducing the virus's ability to multiply and helping control chronic hepatitis B infection. .

🔹 Composition
Active Ingredient: Tenofovir Alafenamide
Strength: 25 mg
Presentation: Bottle of 30 tablets
Dosage Form: Film-coated tablet
Route: Oral
Therapeutic Class: Antiviral / Nucleotide Reverse Transcriptase Inhibitor
Prescription Status: Prescription medicine
Manufacturer/Marketer: Mylan Pharmaceuticals Pvt. Ltd. – A Viatris Company

🔹 Uses And Indications
HepBest 25 mg may be used for:
Chronic hepatitis B virus (HBV) infection
Long-term suppression of HBV replication
Management of chronic hepatitis B in adults with compensated liver disease
Treatment of eligible adolescents aged 12 years and older who meet the required weight and clinical criteria
The specific treatment duration depends on the patient's HBV status, liver condition, treatment response and the treating physician's assessment.

🔹 How It Works
Tenofovir alafenamide is converted inside cells to the active antiviral metabolite tenofovir diphosphate. It inhibits the HBV reverse transcriptase/polymerase enzyme, interfering with viral DNA synthesis and reducing the ability of hepatitis B virus to replicate.

🔹 Key Benefits
Helps suppress hepatitis B virus replication.
Helps reduce HBV viral load during long-term treatment.
Used for chronic hepatitis B management in appropriately selected patients.
Provides targeted antiviral activity against HBV.

🔹 Dosage And Administration
HepBest 25 mg Tablet must be taken only as prescribed by a qualified healthcare professional.
The recommended dosage for eligible adults and adolescents is 25 mg once daily. It should be taken consistently according to the physician's instructions. The Indian prescribing information allows administration with or without food, while some product information recommends administration with food; patients should follow the instructions supplied with their specific product.


🔹 Possible Side Effects
HepBest may cause:
Headache
Nausea
Diarrhea
Abdominal pain
Fatigue
Dizziness
Vomiting
Rash
Weakness
Increased liver enzymes
Changes in kidney function or bone-related parameters may occur and may require monitoring during long-term treatment.

🔹 Precautions And Warnings
Use only under appropriate medical supervision.
Patients should be tested for HIV infection before starting tenofovir alafenamide monotherapy, because it should not be used alone for HIV treatment.
Kidney function should be assessed before and during treatment as clinically appropriate.
Inform the doctor about existing kidney or liver disease.
Patients with decompensated liver disease require specialist assessment because tenofovir alafenamide is not recommended in this setting according to the product information.
Do not discontinue treatment without medical advice because hepatitis B may flare after stopping therapy.
Inform the healthcare professional about all medicines and supplements being taken.
Patients with HIV/HBV coinfection require an appropriate combination antiretroviral regimen rather than tenofovir alafenamide alone.
Pregnancy and breastfeeding should be discussed with the treating physician before use.

🔹 Storage
Store HepBest 25 mg Tablets below 30°C and keep them in the original container. Protect the tablets from excessive heat and moisture and keep out of reach of children. Follow the manufacturer's current package insert for storage and handling requirements.