Product Description

🔹 Product Overview
Durea 500 mg Capsule contains Hydroxyurea 500 mg, an antimetabolite medicine used under specialist medical supervision for certain blood disorders and cancers.
Hydroxyurea works by inhibiting ribonucleotide reductase, an enzyme required for DNA synthesis, thereby slowing the production and division of rapidly proliferating cells.

🔹 Composition
Active Ingredient: Hydroxyurea
Strength: 500 mg
Dosage Form: Capsule
Route: Oral
Pack Size: 10 capsules
Therapeutic Class: Antimetabolite / Antineoplastic agent

🔹 Uses And Indications
Durea 500 mg may be prescribed for:
Sickle cell disease
Certain forms of chronic myeloid leukemia (CML)
Certain advanced head and neck cancers
Other hematological conditions where hydroxyurea is clinically indicated
For sickle cell disease, hydroxyurea can increase fetal hemoglobin (HbF), helping reduce sickling-related complications.

🔹 How It Works
Hydroxyurea inhibits ribonucleotide reductase, reducing DNA synthesis and slowing the proliferation of rapidly dividing cells.
In sickle cell disease, hydroxyurea also increases fetal hemoglobin, which can reduce red blood-cell sickling and help decrease painful vaso-occlusive episodes.

🔹 Key Benefits
Helps manage sickle cell disease when prescribed appropriately.
Can reduce the frequency of painful sickle-cell episodes.
Supports increased fetal hemoglobin production in sickle cell disease.
Used as part of specialist treatment protocols for selected hematological malignancies.
Oral 500 mg capsule formulation provides convenient administration.

🔹 Dosage And Administration
Take Durea exactly as prescribed by the treating physician. The appropriate dose varies according to the condition being treated, blood counts, kidney function, body weight, and individual response.
The capsule may generally be taken with or without food. Regular blood tests are important during treatment to monitor blood-cell counts and treatment safety.
Do not change the dose or discontinue treatment without medical advice.

🔹 Possible Side Effects
Potential adverse effects include:
Nausea or vomiting
Loss of appetite
Diarrhea or constipation
Abdominal discomfort
Fatigue or weakness
Temporary hair loss
Low white blood-cell count
Low red blood-cell count
Low platelet count
Increased susceptibility to infections
Easy bruising or bleeding
Regular laboratory monitoring is important because hydroxyurea can cause bone-marrow suppression.

🔹 Precautions And Warnings
Durea should be used only under specialist medical supervision.
Regular complete blood counts (CBC) are required.
Dose adjustment may be necessary in patients with kidney impairment.
Inform the doctor about liver or kidney disease and previous blood disorders.
Avoid handling damaged capsules directly; caregivers should use appropriate protective measures.
Tell your doctor about all medicines and supplements being taken.
Effective contraception is generally recommended during treatment because hydroxyurea can affect reproductive health.
Pregnancy and breastfeeding require specific medical advice.
Seek medical attention for fever, unusual bleeding, severe weakness, or signs of infection.

🔹 Storage
Store below 30°C and protect from excessive heat and moisture. Keep the capsules out of reach of children.