Product Description

🔹 Product Overview
BIOVORIN 50 mg Injection is a medication containing Calcium Leucovorin (Folinic Acid) 50 mg. It is commonly used in oncology to reduce the toxic effects of certain chemotherapy medicines, particularly methotrexate, and as part of combination therapy for colorectal cancer. It may also be used in the management of accidental methotrexate overdose or folic acid antagonist toxicity under medical supervision.

🔹 Key Uses
Reduces the harmful effects of high-dose methotrexate (Leucovorin rescue)
Treatment of methotrexate overdose
Management of folic acid antagonist toxicity
Used in combination with 5-fluorouracil (5-FU) for the treatment of colorectal cancer
May be prescribed for other approved indications as determined by an oncologist.

🔹 Composition
Active Ingredient: Calcium Leucovorin (Folinic Acid) 50 mg/5 mL
Drug Class: Folinic Acid Derivative
Chemoprotective Agent
Antidote to Folic Acid Antagonists

🔹 How It Works
BIOVORIN contains Leucovorin (Folinic Acid), an active form of folic acid that helps protect healthy cells from the toxic effects of medications such as methotrexate without significantly reducing their therapeutic effect. When used with 5-fluorouracil (5-FU), leucovorin enhances the anticancer activity of 5-FU by increasing its binding to cancer cells, improving treatment effectiveness.

🔹 Key Benefits
Helps minimize methotrexate-induced toxicity
Reduces the risk of severe side effects associated with chemotherapy
Supports recovery of healthy cells following high-dose methotrexate therapy
Enhances the effectiveness of 5-fluorouracil in colorectal cancer treatment
Widely used in hospital oncology protocols
Administered by trained healthcare professionals for accurate dosing

🔹 Dosage and Administration
Administer only under the supervision of a qualified healthcare professional.
Given by intravenous (IV) or intramuscular (IM) injection, depending on the prescribed treatment regimen.
The dosage and duration depend on:
Type of chemotherapy
Methotrexate dose
Kidney function
Blood test results
Patient's clinical condition
Follow the treatment schedule recommended by your oncologist.
Do not self-administer this injection.

🔹 Possible Side Effects
Common side effects may include:
Nausea
Vomiting
Injection site discomfort
Fever
Fatigue
Mild allergic reactions
Rare but serious side effects include:
Severe allergic reactions
Difficulty breathing
Skin rash or swelling
Seizures (rare)
Severe gastrointestinal symptoms
Seek immediate medical attention if serious side effects occur.

🔹 Precautions
Use only under medical supervision.
Inform your doctor if you have kidney or liver disease.
Tell your healthcare provider about any allergies to folinic acid or related medicines.
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
Regular monitoring of blood counts and kidney function may be required during treatment.
Follow all laboratory testing and monitoring schedules advised by your healthcare provider.